What’s CAR-T Therapy? How does it work?

Chimeric Antigen Receptor T-Cell Immunotherapy OR CAR-T therapy. It’s a type of treatment in which a patient’s T cells (a type of immune system cell) are changed in the laboratory so they will attack cancer cells.

T cells are taken from a patient’s blood. Then the gene for a special receptor that binds to a certain protein on the patient’s cancer cells is added to the T cells in the laboratory. The special receptor is called a chimeric antigen receptor (CAR). Large numbers of the CAR T cells are grown in the laboratory and given to the patient by infusion.

CAR T-cell therapy is used to treat certain blood cancers such as

  • B-Cell Acute Lymphoblastic Leukemia
  • T-cell Acute Lymphoblastic Leukemia
  • B-Cell Lymphoma
  • Multiple Myeloma

It is being studied in the treatment of other types of cancer. Also called chimeric antigen receptor T-cell therapy.

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